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Article

Combined myofibrillar and mitochondrial creatine kinase deficiency impairs mouse diaphragm isotonic function.

Journal of applied physiology (Bethesda, Md. : 1985) - 1 May 1997

Watchko J F, Daood M J, Sieck G C, LaBella J J, Ameredes B T, Koretsky A P, Wieringa B

Abstract excerpt

Creatine kinase (CK) is an enzyme central to cellular high-energy phosphate metabolism in muscle. To characterize the physiological role of CK in respiratory muscle during dynamic contractions, we compared the force-velocity relationships, power, and work output characteristics of the diaphragm (Dia) from mice with combined myofibrillar and sarcomeric mitochondrial CK deficiency (CK[-/-]) with CK-sufficient...

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PMID: 9134887
DOI: 10.1152/jappl.1997.82.5.1416

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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