Article
Combined myofibrillar and mitochondrial creatine kinase deficiency impairs mouse diaphragm isotonic function.
Journal of applied physiology (Bethesda, Md. : 1985) - 1 May 1997
Watchko J F, Daood M J, Sieck G C, LaBella J J, Ameredes B T, Koretsky A P, Wieringa B
Abstract excerpt
Creatine kinase (CK) is an enzyme central to cellular high-energy phosphate metabolism in muscle. To characterize the physiological role of CK in respiratory muscle during dynamic contractions, we compared the force-velocity relationships, power, and work output characteristics of the diaphragm (...
Topics
- Adenosine Triphosphatases
- Animals
- Creatine Kinase
- Diaphragm
- Isomerism
- Isotonic Contraction
- Mice
- Mice, Mutant Strains
- Mitochondria
- Muscle Fatigue
- Mutagenesis
- Myofibrils
- Myosin Heavy Chains
- Phenotype