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Article

Altered Ca2+ concentration, permeability and buffering in the myofibre Ca2+ store of a mouse model of malignant hyperthermia.

The Journal of physiology - 15 Sept 2013

Manno Carlo, Figueroa Lourdes, Royer Leandro, Pouvreau Sandrine, Lee Chang Seok, Volpe Pompeo, Nori Alessandra, Zhou Jingsong, Meissner Gerhard, Hamilton Susan L, Ríos Eduardo

Abstract excerpt

Malignant hyperthermia (MH) is linked to mutations in the type 1 ryanodine receptor, RyR1, the Ca2+ channel of the sarcoplasmic reticulum (SR) of skeletal muscle. The Y522S MH mutation was studied for its complex presentation, which includes structurally and functionally altered cell 'cores'. Imaging cytosolic and intra-SR [Ca2+] in muscle cells of heterozygous YS mice we determined Ca2+ release flux activated by...

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Identifiers

PMID: 23798496
DOI: 10.1113/jphysiol.2013.259572
PMCID: PMC3784192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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