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Article

Potassium dependent rescue of a myopathy with core-like structures in mouse.

eLife - 7 Jan 2015

Hanson M Gartz, Wilde Jonathan J, Moreno Rosa L, Minic Angela D, Niswander Lee

Abstract excerpt

Myopathies decrease muscle functionality. Mutations in ryanodine receptor 1 (RyR1) are often associated with myopathies with microscopic core-like structures in the muscle fiber. In this study, we identify a mouse RyR1 model in which heterozygous animals display clinical and pathological hallmarks of myopathy with core-like structures. The RyR1 mutation decreases sensitivity to activated calcium release and...

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Identifiers

PMID: 25564733
DOI: 10.7554/eLife.02923
PMCID: PMC4309926

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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