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Article

Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors.

Endocrinology - 1 Oct 1998

Liu Y, Takeshita A, Misiti S, Chin W W, Yen P M

Abstract excerpt

We studied the interactions of two natural thyroid hormone receptor (TR) mutants from patients with resistance to thyroid hormone (RTH) and an artificial TR mutant with a nuclear receptor corepressor, N-CoR, and a steroid receptor coactivator, SRC-1. In electrophoretic mobility shift assays, wild...

Topics

DNA
Histone Acetyltransferases
Humans
Mutation
Nuclear Proteins
Nuclear Receptor Co-Repressor 1
Nuclear Receptor Coactivator 1
Receptors, Thyroid Hormone
Repressor Proteins
Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9751500
DOI: 10.1210/endo.139.10.6218

Genes

SRC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9751500-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors.PMID 9751500Read ↗

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A novel natural mutation in the thyroid hormone receptor defines a dual functional domain that exchanges nuclear receptor corepressors and coactivators.Semantic proximity Read ↗

Nuclear corepressors enhance the dominant negative activity of mutant receptors that cause resistance to thyroid hormone.Semantic proximity Read ↗

Thyroid hormone resistance syndrome manifests as an aberrant interaction between mutant T3 receptors and transcriptional corepressors.Semantic proximity Read ↗

Thyroid hormone signaling in vivo requires a balance between coactivators and corepressors.Semantic proximity Read ↗

Resistance to thyroid hormone (RTH) syndrome reveals novel determinants regulating interaction of T3 receptor with corepressor.Semantic proximity Read ↗

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Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1).Semantic proximity Read ↗

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Very strong correlation between dominant negative activities of mutant thyroid hormone receptors and their binding avidity for corepressor SMRT.Semantic proximity Read ↗

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