Article
Inferring the conformation of RNA base pairs and triples from patterns of sequence variation.
Nucleic acids research - 15 Apr 1997
Gautheret D, Gutell R R
Abstract excerpt
The success of comparative analysis in resolving RNA secondary structure and numerous tertiary interactions relies on the presence of base covariations. Although the majority of base covariations in aligned sequences is associated to Watson-Crick base pairs, many involve non-canonical or restricted base pair exchanges (e.g. only G:C/A:U), reflecting more specific structural constraints. We have developed a...
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