Article
Computational detection of abundant long-range nucleotide covariation in Drosophila genomes.
RNA (New York, N.Y.) - 1 Sept 2013
Bindewald Eckart, Shapiro Bruce A
Abstract excerpt
Functionally important nucleotide base-pairing often manifests itself in sequence alignments in the form of compensatory base changes (covariation). We developed a novel index-based computational method (CovaRNA) to detect long-range covariation on a genomic scale, as well as another computational method (CovStat) for determining the statistical significance of observed covariation patterns in alignment pairs....
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