Article
Identifying novel sequence variants of RNA 3D motifs.
Nucleic acids research - 3 Sept 2015
Zirbel Craig L, Roll James, Sweeney Blake A, Petrov Anton I, Pirrung Meg, Leontis Neocles B
Abstract excerpt
Predicting RNA 3D structure from sequence is a major challenge in biophysics. An important sub-goal is accurately identifying recurrent 3D motifs from RNA internal and hairpin loop sequences extracted from secondary structure (2D) diagrams. We have developed and validated new probabilistic models for 3D motif sequences based on hybrid Stochastic Context-Free Grammars and Markov Random Fields (SCFG/MRF). The...
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