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Article

Phylogenetic and genetic evidence for base-triples in the catalytic domain of group I introns.

Nature - 11 Oct 1990

Michel F, Ellington A D, Couture S, Szostak J W

Abstract excerpt

Understanding the mechanisms by which ribozymes catalyse chemical reactions requires a detailed knowledge of their structure. The secondary structure of the group I introns has been confirmed by comparison of over 70 published sequences, by chemical protection studies, and by genetic experiments involving compensatory mutations. Phylogenetic data can also be used to identify tertiary interactions in RNA...

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Identifiers

PMID: 2215683
DOI: 10.1038/347578a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phylogenetic and genetic evidence for base-triples in the catalytic domain of group I introns.PMID 2215683Read ↗

Mutagenesis and comparative sequence analysis of a base triple joining the two domains of group I ribozymes.Semantic proximity Read ↗

In vitro genetic analysis of the hinge region between helical elements P5-P4-P6 and P7-P3-P8 in the sunY group I self-splicing intron.Semantic proximity Read ↗

New loop-loop tertiary interactions in self-splicing introns of subgroup IC and ID: a complete 3D model of the Tetrahymena thermophila ribozyme.Semantic proximity Read ↗

A broadscale phylogenetic analysis of group II intron RNAs and intron-encoded reverse transcriptases.Semantic proximity Read ↗

Base-pairing interactions involving the 5' and 3'-terminal nucleotides of group II self-splicing introns.Semantic proximity Read ↗

An important base triple anchors the substrate helix recognition surface within the Tetrahymena ribozyme active site.Semantic proximity Read ↗

Role of a conserved J8/7 X P4 base-triple in the Tetrahymena ribozyme.Semantic proximity Read ↗

Structure of the P1 helix from group I self-splicing introns.Semantic proximity Read ↗

A 3' splice site-binding sequence in the catalytic core of a group I intron.Semantic proximity Read ↗

Accurate, comprehensive database of group I introns and their homing endonucleasesSemantic proximity Read ↗

Complex selection on 5' splice sites in intron-rich organisms.Semantic proximity Read ↗

The ins and outs of group II introns.Semantic proximity Read ↗

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