Article
Inhibition of nitric oxide synthase causes cardiac phenotypic modulation in rat.
European journal of pharmacology - 12 Mar 1997
Takaori K, Kim S, Ohta K, Hamaguchi A, Yagi K, Iwao H
Abstract excerpt
Cardiac gene expressions of collagen and contractile proteins were examined in rats treated with a nitric oxide (NO) synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME), for 3 weeks. The rats became hypertensive, which caused left ventricular hypertrophy. Among the mRNAs examined, beta-...
Topics
- Angiotensin II
- Angiotensin Receptor Antagonists
- Animals
- Biphenyl Compounds
- Blotting, Northern
- Collagen
- Contractile Proteins
- DNA Probes
- Enzyme Inhibitors
- Gene Expression Regulation
- Heart
- Imidazoles
- Losartan
- Male
- Myocardium
- NG-Nitroarginine Methyl Ester
- Nitric Oxide Synthase
- Organ Size