Article
AT1 receptor antagonist therapy preferentially ameliorated right ventricular function and phenotype during the early phase of remodeling post-MI.
British journal of pharmacology - 1 Apr 2003
Nguyen Quang T, Colombo Federico, Clement Robert, Gosselin Hugues, Rouleau Jean-Lucien, Calderone Angelino
Abstract excerpt
1. The influence of AII on contractile dysfunction, regulation of the tyrosine kinase-dependent signaling molecule extracellular signal-regulated kinase (ERK), and natriuretic peptide gene expression were examined in the noninfarcted left ventricle (NILV) and right ventricle (RV) during the early phase of remodeling post-myocardial infarct (MI) in the rat. The selective AT(1) receptor antagonist irbesartan was...
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