Angiotensin II induces cardiac phenotypic modulation and remodeling in vivo in rats.

doi:10.1161/01.hyp.25.6.1252

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Article

Angiotensin II induces cardiac phenotypic modulation and remodeling in vivo in rats.

Hypertension (Dallas, Tex. : 1979) - 1 Jun 1995

Kim S, Ohta K, Hamaguchi A, Yukimura T, Miura K, Iwao H

Abstract excerpt

Cardiac phenotypic modulation and remodeling appear to be involved in the pathophysiology of cardiac hypertrophy and heart failure. We undertook this study to examine whether angiotensin II (Ang II) in vivo, independent of blood pressure, contributes to cardiac phenotypic modulation and remodelin...

Topics

Actins
Angiotensin II
Animals
Atrial Natriuretic Factor
Base Sequence
Body Weight
Cardiomegaly
Collagen
Gene Expression
Heart
Male
Molecular Sequence Data
Phenotype
RNA, Messenger
Rats
Rats, Wistar
Transforming Growth Factor beta

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