Article
Sympathetic activity: modulator of myocardial hypertrophy.
Journal of cardiovascular pharmacology - 1 Jan 1991
Long C S, Kariya K, Karns L, Simpson P C
Abstract excerpt
The mechanisms regulating myocardial hypertrophy are largely unknown. Furthermore, the hypertrophic phenotype can be associated with either normal or abnormal function. To study the molecular mechanisms involved in myocardial hypertrophy, we have established a cell culture system in which stimulation of the alpha 1-adrenergic receptor leads to the development of myocardial cell hypertrophy. In addition to...
Topics
- Animals
- Cardiomegaly
- Catecholamines
- Cells, Cultured
- Models, Cardiovascular
- Phenotype
- Protein Biosynthesis
- Rats
- Receptors, Adrenergic, alpha
- Signal Transduction