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Article

Collagen phenotypes during development and regression of myocardial hypertrophy in spontaneously hypertensive rats.

Circulation research - 1 Dec 1990

Mukherjee D, Sen S

Abstract excerpt

The myocardium contains collagen matrix that is a major determinant of its architecture, structural integrity, and mechanical properties. This fibrillar matrix consists primarily of type I and type III collagens having epimysial, perimysial, and endomysial components. The present study shows the alteration of collagen phenotypes during the evolution of hypertensive hypertrophy. Therapy with captopril, an...

Topics

Age Factors
Animals
Captopril
Cardiomegaly
Collagen
Cyanogen Bromide
Female
Hydroxyproline
Hypertension
Male
Myocardium
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats

Rats, Inbred SHR

Rats, Inbred Strains

Rats, Inbred WKY

Spectrophotometry

Source

Identifiers

PMID: 2147130
DOI: 10.1161/01.res.67.6.1474

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2147130-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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