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Article

Interleukin-1 beta modulates the growth and phenotype of neonatal rat cardiac myocytes.

The Journal of clinical investigation - 1 Aug 1995

Thaik C M, Calderone A, Takahashi N, Colucci W S

Abstract excerpt

Mononuclear cell infiltration and local cytokine elaboration are hallmarks of inflammatory and immunologic heart diseases. To test the hypothesis that cytokines can modulate cardiac myocyte growth and phenotype, myocytes cultured from neonatal rat hearts were exposed to IL-1 beta, an inflammatory cytokine prevalent in myocardial inflammation. IL-1 beta (2 ng/ml, 24 h) increased [3H]leucine incorporation by 30 +/-...

Topics

Animals
Animals, Newborn
Calcium
Cell Division
Cells, Cultured
Gene Expression Regulation
Genes, Regulator
Heart
Interleukin-1
Myocardium
Phenotype
Rats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7635944
DOI: 10.1172/JCI118095
PMCID: PMC185298

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7635944-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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