Article
Interleukin-1 beta modulates the growth and phenotype of neonatal rat cardiac myocytes.
The Journal of clinical investigation - 1 Aug 1995
Thaik C M, Calderone A, Takahashi N, Colucci W S
Abstract excerpt
Mononuclear cell infiltration and local cytokine elaboration are hallmarks of inflammatory and immunologic heart diseases. To test the hypothesis that cytokines can modulate cardiac myocyte growth and phenotype, myocytes cultured from neonatal rat hearts were exposed to IL-1 beta, an inflammatory cytokine prevalent in myocardial inflammation. IL-1 beta (2 ng/ml, 24 h) increased [3H]leucine incorporation by 30 +/-...
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