Article
Differences in mutational patterns between rheumatoid factors in health and disease are related to variable heavy chain family and germ-line gene usage.
European journal of immunology - 1 Mar 1997
Børretzen M, Chapman C, Natvig J B, Thompson K M
Abstract excerpt
The sequences of the heavy chain variable (V(H)) segment and dissociation constants (Kd) of 14 IgM rheumatoid factors (RF) derived from 11 different germline gene segments from five healthy immunized donors (HID) are described. We extend a previous analysis of two clones from one donor using only...
Topics
- Amino Acid Sequence
- Antibody Affinity
- Antibody Diversity
- Arthritis, Rheumatoid
- Dose-Response Relationship, Immunologic
- Genes, Immunoglobulin
- Humans
- Immunoglobulin M
- Immunoglobulin Variable Region
- Immunoglobulin mu-Chains
- Molecular Sequence Data
- Mutation
- Rheumatoid Factor
- Sequence Alignment
- Sequence Homology, Amino Acid