Article
V-gene repertoire and hypermutation of rheumatoid factors produced in rheumatoid synovial inflammation and immunized healthy donors.
Annals of the New York Academy of Sciences - 29 Sept 1995
Thompson K M, Børretzen M, Randen I, Førre O, Natvig J B
Abstract excerpt
We have compared RF from normal, immunized donors and RF derived from the synovial tissues of RA patients. We have found a difference in the preferential use of VL and VH gene families. In both conditions, RFs were found to have accumulated somatic mutations. However, there was a striking differe...
Topics
- Antibody Affinity
- Arthritis, Juvenile
- Arthritis, Rheumatoid
- Autoimmune Diseases
- Base Sequence
- Blood Group Incompatibility
- Cross Reactions
- Gene Rearrangement, B-Lymphocyte
- Genes, Immunoglobulin
- Humans
- Immunization
- Immunoglobulin Heavy Chains
- Immunoglobulin Idiotypes
- Immunoglobulin M