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Article

Promoter-selective transcriptional defect in cell cycle mutant ts13 rescued by hTAFII250.

Science (New York, N.Y.) - 11 Feb 1994

Wang E H, Tjian R

Abstract excerpt

The TAFII250 subunit of the human transcription factor IID (TFIID) rescues the temperature-sensitive hamster cell line ts13 and overcomes a G1 arrest. Investigation of the transcriptional properties of ts13 nuclear extracts in vitro showed that activation by the site-specific regulators Sp1 and Gal4VP16 is temperature sensitive in ts13 extracts, whereas basal transcription remains unaffected. This transcriptional...

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Identifiers

PMID: 8303298
DOI: 10.1126/science.8303298

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Promoter-selective transcriptional defect in cell cycle mutant ts13 rescued by hTAFII250.PMID 8303298Read ↗

TAFII250-dependent transcription of cyclin A is directed by ATF activator proteins.Semantic proximity Read ↗

Requirement for TAF(II)250 acetyltransferase activity in cell cycle progression.Semantic proximity Read ↗

Differential regulation of transcription of p21 and cyclin D1 conferred by TAF(II)250.Semantic proximity Read ↗

TAF1 histone acetyltransferase activity in Sp1 activation of the cyclin D1 promoter.Semantic proximity Read ↗

D-type cyclin expression is decreased and p21 and p27 CDK inhibitor expression is increased when tsBN462 CCG1/TAFII250 mutant cells arrest in G1 at the restrictive temperature.Semantic proximity Read ↗

Different functional domains of TAFII250 modulate expression of distinct subsets of mammalian genes.Semantic proximity Read ↗

Minimum essential region of CCG1/TAFII250 required for complementing the temperature-sensitive cell cycle mutants, tsBN462 and ts13 cells, of hamster BHK21 cells.Semantic proximity Read ↗

Herpes simplex virus 1 late gene expression is preferentially inhibited during infection of the TAF250 mutant ts13 cell line.Semantic proximity Read ↗

A TATA-binding protein mutant defective for TFIID complex formation in vivo.Semantic proximity Read ↗

Human TAFII250 interacts with RAP74: implications for RNA polymerase II initiation.Semantic proximity Read ↗

Distinct mutations in yeast TAF(II)25 differentially affect the composition of TFIID and SAGA complexes as well as global gene expression patterns.Semantic proximity Read ↗

Yeast TAF(II)90 is required for cell-cycle progression through G2/M but not for general transcription activation.Semantic proximity Read ↗

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