Promoter-selective transcriptional defect in cell cycle mutant ts13 rescued by hTAFII250.

doi:10.1126/science.8303298

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Article

Promoter-selective transcriptional defect in cell cycle mutant ts13 rescued by hTAFII250.

Science (New York, N.Y.) - 11 Feb 1994

Wang E H, Tjian R

Abstract excerpt

The TAFII250 subunit of the human transcription factor IID (TFIID) rescues the temperature-sensitive hamster cell line ts13 and overcomes a G1 arrest. Investigation of the transcriptional properties of ts13 nuclear extracts in vitro showed that activation by the site-specific regulators Sp1 and G...

Topics

Animals
Cell Line
Cyclins
DNA-Binding Proteins
Fungal Proteins
G1 Phase
Genes, fos
Genetic Complementation Test
Genetic Vectors
Histone Acetyltransferases
Humans
Mutation
Nuclear Proteins
Promoter Regions, Genetic
Sp1 Transcription Factor
TATA-Binding Protein Associated Factors
Temperature
Trans-Activators

Source

Open in PubMed

Identifiers

PMID: 8303298
DOI: 10.1126/science.8303298

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8303298-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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