Article
Defect in the p53-Mdm2 autoregulatory loop resulting from inactivation of TAF(II)250 in cell cycle mutant tsBN462 cells.
Molecular and cellular biology - 1 Aug 2000
Wasylyk C, Wasylyk B
Abstract excerpt
The cell cycle arrest and proapoptotic functions of p53 are under tight control by Mdm2. After stress activation of p53 by nontranscriptional mechanisms, transcription of the mdm2 gene results in increased synthesis of Mdm2 and down-regulation of p53. Disruption of this autoregulatory loop has profound effects on cell survival and tumorigenesis. We show that a defective p53-Mdm2 autoregulatory loop results from...
Topics
- Animals
- Cell Cycle
- Cell Cycle Proteins
- Cell Line
- Cricetinae
- Cyclin A
- DNA-Binding Proteins
- Gene Silencing
- Histone Acetyltransferases
- Kinetics
- Mutation
- Nuclear Proteins
- Promoter Regions, Genetic
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-mdm2