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Article

Differential susceptibility to seizures induced by systemic kainic acid treatment in mature DBA/2J and C57BL/6J mice.

Epilepsia - 1 Mar 1995

Ferraro T N, Golden G T, Smith G G, Berrettini W H

Abstract excerpt

Mature DBA/2J (D2) and C57BL/6J (B6) mice aged 9-10 weeks were studied to determine susceptibility to behavioral seizures induced by kainic acid (KA) and the possible influence exerted by differences in metabolism and blood-brain barrier (BBB) transport. Mice were observed for 4 h after subcutaneous (s.c.) KA injection. Behavioral seizure parameters included latency to first seizure (clonus), latency to...

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PMID: 7614915
DOI: 10.1111/j.1528-1157.1995.tb00999.x

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