Article
Genetic control of sensitivity to hippocampal cell death induced by kainic acid: a quantitative trait loci analysis.
The Journal of comparative neurology - 6 Sept 2004
Schauwecker Paula Elyse, Williams Robert W, Santos Julia Belen
Abstract excerpt
Host genetic factors are likely to contribute to differences in individual susceptibility to seizure-induced excitotoxic neuronal damage. Similarly, inbred strains of mice differ in their susceptibility to the kainic acid (KA) model of seizure-induced cell death, but the genes responsible for the differences are not known. Here, we define the inheritance patterns of susceptibility to KA-induced neurodegeneration...
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