Article
Childhood/early adolescence-onset and adult-onset schizophrenia. Heterogeneity at the dopamine D3 receptor gene.
The British journal of psychiatry : the journal of mental science - 1 Jan 1997
Maziade M, Martinez M, Rodrigue C, Gauthier B, Tremblay G, Fournier C, Bissonnette L, Simard C, Roy M A, Rouillard E, Mérette C
Abstract excerpt
BACKGROUND: The dopamine D3 receptor gene (DRD3) is a meaningful candidate gene because it unifies the dopamine and the limbic hypotheses for schizophrenia. We tested for an allelic association between schizophrenia and the DRD3 Mscl alleles, hypothesising heterogeneity between childhood/early adolescence-onset schizophrenia (CO-SZ) and adult-onset schizophrenia (A-SZ). METHOD: The frequencies of the DRD3 alleles...
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