Article
Converging evidence implicates the dopamine D3 receptor gene in vulnerability to schizophrenia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jul 2011
Zhang Fuquan, Fan Hua, Xu Yong, Zhang Kerang, Huang Xuezhu, Zhu Yan, Sui Manqiu, Sun Gaoxiang, Feng Kun, Xu Bo, Zhang Xiaoqian, Su Zhonghua, Peng Chunqing, Liu Pozi
Abstract excerpt
The dopamine D3 receptor has been implicated in the pathophysiology of schizophrenia (SZ). A glycine-to-serine polymorphism at codon 9 of the dopamine D3 receptor gene (DRD3), rs6280, has been widely studied for its association with SZ, but with conflicting results. Altered levels of DRD3 mRNA have also been reported in SZ compared with normal controls. Moreover, it has been suggested that DRD3 is subject to...
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