Article
Genetic association between the dopamine D3 gene polymorphism (Ser9Gly) and schizophrenia in Japanese populations: evidence from a case-control study and meta-analysis.
Neuroscience letters - 24 Oct 2008
Utsunomiya Kensuke, Shinkai Takahiro, De Luca Vincenzo, Hwang Rudi, Sakata Shinichi, Fukunaka Yuko, Chen Hsin-I, Ohmori Osamu, Nakamura Jun
Abstract excerpt
Dysregulation in the dopaminergic system has been implicated in the pathophysiology of schizophrenia (SCZ). Dopamine D3 receptors (DRD3) concentrated in limbic regions of the brain (important for cognitive, emotional and endocrine function) may be particularly relevant to SCZ. A recent meta-analysis with mixed ethnicities reported a marginal significant association between the Ser9Gly homozygosity in the first...
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