Article
Novel, replicated associations between dopamine D3 receptor gene polymorphisms and schizophrenia in two independent samples.
Biological psychiatry - 15 Sept 2006
Talkowski Michael E, Mansour Hader, Chowdari Kodavali V, Wood Joel, Butler Allison, Varma Panchami G, Prasad Suman, Semwal Prachi, Bhatia Triptish, Deshpande Smita, Devlin Bernie, Thelma B K, Nimgaonkar Vishwajit L
Abstract excerpt
BACKGROUND: Meta-analyses have suggested an association between schizophrenia (SZ) and a coding polymorphism (rs6280/Ser9Gly) at the dopamine D3 receptor gene (DRD3), but results have been inconsistent. Because most studies have evaluated only rs6280, the inconsistencies might reflect associations with other variants. METHODS: We analyzed polymorphisms spanning 109kb in two independent samples (United States: 13...
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