Article
Association study of BDNF and DRD3 genes in schizophrenia diagnosis using matched case-control and family based study designs.
Progress in neuro-psychopharmacology & biological psychiatry - 1 Dec 2010
Zai Clement C, Manchia Mirko, De Luca Vincenzo, Tiwari Arun K, Squassina Alessio, Zai Gwyneth C, Strauss John, Shaikh Sajid A, Freeman Natalie, Meltzer Herbert Y, Lieberman Jeffrey, Le Foll Bernard, Kennedy James L
Abstract excerpt
Schizophrenia (SCZ) is a severe neuropsychiatric disorder with prominent genetic etiologic factors. The dopamine receptor DRD3 gene is a strong candidate in genetic studies of SCZ because of the dopamine hypothesis of SCZ and the selective expression of D(3) in areas of the limbic system implicated in the disease. We examined 15 single-nucleotide polymorphisms (SNPs) in DRD3 in our sample of European origin...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.