Article
Fine-scale mapping of the gene responsible for multiple endocrine neoplasia type 1 (MEN 1).
American journal of human genetics - 1 Feb 1992
Fujimori M, Wells S A, Nakamura Y
Abstract excerpt
We have constructed a high-resolution genetic linkage map in the vicinity of the gene responsible for multiple endocrine neoplasia type 1 (MEN1). The mutation causing this disease, inherited as an autosomal dominant, predisposes carriers to development of neoplastic tumors in the parathyroid, the endocrine pancreas, and the anterior lobe of the pituitary. The 12 markers on the genetic linkage map reported here...
Topics
- Alleles
- Chromosome Banding
- Chromosomes, Human, Pair 11
- Endocrine Gland Neoplasms
- Female
- Genes, Dominant
- Genetic Linkage
- Humans
- Male
- Neoplasms, Multiple Primary
- Pancreatic Neoplasms