Article
Circumventing multiple testing: a multilocus Monte Carlo approach to testing for association.
Genetic epidemiology - 1 Jul 2000
McIntyre L M, Martin E R, Simonsen K L, Kaplan N L
Abstract excerpt
Advances in marker technology have made a dense marker map a reality. If each marker is considered separately, and separate tests for association with a disease gene are performed, then multiple testing becomes an issue. A common solution uses a Bonferroni correction to account for multiple tests performed. However, with dense marker maps, neighboring markers are tightly linked and may have associated alleles;...
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