Article
Molecular analysis of p53 gene in laryngeal premalignant and malignant lesions. p53 protein immunohistochemical expression is positively related to proliferating cell nuclear antigen labelling index.
Virchows Archiv : an international journal of pathology - 1 Jan 1995
Gorgoulis V, Zoumpourlis V, Rassidakis G, Karameris A, Barbatis C, Spandidos D A, Kittas C
Abstract excerpt
This study was undertaken in order to investigate the molecular nature of the p53 gene in 19 laryngeal squamous cell carcinomas and dysplasias. Moreover, we have examined the possible relationship between proliferating cell nuclear antigen (PCNA) expression and p53 protein detection status in 42...
Topics
- Base Sequence
- Carcinoma, Squamous Cell
- Cell Division
- Humans
- Immunohistochemistry
- Laryngeal Neoplasms
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Precancerous Conditions
- Proliferating Cell Nuclear Antigen
- Tumor Suppressor Protein p53