Hepatic messenger RNA contents of cytochrome P4502E1 in patients with different P4502E1 genotypes.

Article

Hepatic messenger RNA contents of cytochrome P4502E1 in patients with different P4502E1 genotypes.

Alcohol and alcoholism (Oxford, Oxfordshire). Supplement - 1 Jan 1994

Tsutsumi M, Wang J S, Takase S, Takada A

Abstract excerpt

Since heavy drinkers do not always develop alcoholic liver disease (ALD), genetic factors may be involved. Cytochrome P4502E1 (P4502E1) is the main enzyme that oxidizes ethanol in the non-alcohol dehydrogenase pathway. Recently, the presence of genetic polymorphisms at the 5'-flanking region of t...

Topics

Cytochrome P-450 CYP2E1
Ethanol
Gene Amplification
Genotype
Humans
Liver
Polymerase Chain Reaction
Polymorphism, Genetic
RNA, Messenger

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.