Article
Molecular cloning and expression of novel alternatively spliced cytochrome P450 2E1 mRNAs in humans.
Molecular and cellular biochemistry - 1 Dec 2005
Bauer Mario, Herbarth Olf, Aust Gabi, Graebsch Carolin
Abstract excerpt
Human cytochrome P450 2E1 (CYP2E1) is a phase I metabolizing enzyme. It is involved in the biotransformation of xenobiotics and endogenous substrates. Inter-individual genetic polymorphisms of the CYP2E1 gene are associated with different cancer diseases as well as alcohol and nicotine dependence. We report here for the first time three novel alternative spliced mRNA transcripts which are more frequently present...
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