Article
No association between the c2 allele at the cytochrome P450IIE1 gene and alcohol induced liver disease, alcohol Korsakoff's syndrome or alcohol dependence syndrome.
Drug and alcohol dependence - 1 Oct 1995
Ball D M, Sherman D, Gibb R, Powell J F, Hillman A, Peters T, Murray R, Smith I
Abstract excerpt
Cytochrome P450IIE1 metabolises, and is induced by ethanol. The 5' regulatory sequence of the gene is polymorphic; that identified by the c2 allele has been shown by transfection studies to confer an increased rate of transcription. A recent report indicating an association between this allele an...
Topics
- Alcohol Amnestic Disorder
- Alcoholism
- Alleles
- Cytochrome P-450 CYP2E1
- Cytochrome P-450 Enzyme System
- Cytochrome c Group
- Cytochromes c2
- Ethanol
- Gene Frequency
- Genotype
- Heterozygote
- Humans
- Liver Cirrhosis, Alcoholic
- Oxidoreductases, N-Demethylating