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Article

Initiation, elongation, and processivity of carboxyl-terminal mutants of T7 RNA polymerase.

Biochemistry - 11 Mar 1997

Gardner L P, Mookhtiar K A, Coleman J E

Abstract excerpt

Bacteriophage T7 RNA polymerase is a single-subunit enzyme which has a C-terminal amino acid sequence of Phe-Ala-Phe-Ala883 (FAFA883). Closely related hydrophobic sequences are present at the C termini of seven other single-subunit RNA polymerases, including the mitochondrial RNA polymerase. Mutations at any of the four C-terminal residues depress initiation rates of T7 RNA polymerase from 50 to 95%, accompanied...

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Identifiers

PMID: 9062120
DOI: 10.1021/bi962397i

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Initiation, elongation, and processivity of carboxyl-terminal mutants of T7 RNA polymerase.PMID 9062120Read ↗

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