Lactate dehydrogenase-elevating virus variants: cosegregation of neuropathogenicity and impaired capability for high viremic persistent infection.

doi:10.3109/13550289809113501

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Article

Lactate dehydrogenase-elevating virus variants: cosegregation of neuropathogenicity and impaired capability for high viremic persistent infection.

Journal of neurovirology - 1 Oct 1998

Chen Z, Li K, Rowland R R, Anderson G W, Plagemann P G

Abstract excerpt

Neuropathogenic isolates of lactate dehydrogenase virus (LDV) differ from non-neuropathogenic isolates in their unique ability to cause a paralytic disease (age-dependent poliomyelitis, ADPM) in immunosuppressed C58 and AKR mice by cytocidally infecting their anterior horn neurons. We have recent...

Topics

Amino Acid Sequence
Animals
Arterivirus Infections
Base Sequence
Cloning, Molecular
Genetic Variation
Glycosylation
Lactate dehydrogenase-elevating virus
Mice
Molecular Sequence Data
Nervous System Diseases
Phenotype
Reverse Transcriptase Polymerase Chain Reaction
Sequence Alignment
Viral Proteins
Viremia

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Identifiers

PMID: 9839654
DOI: 10.3109/13550289809113501

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9839654-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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