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Article

Lactate dehydrogenase-elevating virus variants: cosegregation of neuropathogenicity and impaired capability for high viremic persistent infection.

Journal of neurovirology - 1 Oct 1998

Chen Z, Li K, Rowland R R, Anderson G W, Plagemann P G

Abstract excerpt

Neuropathogenic isolates of lactate dehydrogenase virus (LDV) differ from non-neuropathogenic isolates in their unique ability to cause a paralytic disease (age-dependent poliomyelitis, ADPM) in immunosuppressed C58 and AKR mice by cytocidally infecting their anterior horn neurons. We have recently reported that an original neuropathogenic LDV isolate, LDV-C-BR, contained a low level of a coexisting...

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PMID: 9839654
DOI: 10.3109/13550289809113501

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