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Article

Peripheral replication and latency reactivation kinetics of the non-neurovirulent herpes simplex virus type 1 variant 1716.

The Journal of general virology - 1 Apr 1992

Robertson L M, MacLean A R, Brown S M

Abstract excerpt

The terminal portion of the herpes simplex virus (HSV) genome long repeat region has been shown to contain a neurovirulence gene. Both HSV-1 and HSV-2 mutants deleted in this gene fail to cause central nervous system (CNS) disease in mice. The HSV-1 strain 17 variant 1716, which has a 759 bp deletion encompassing the gene, grows normally in tissue culture but fails to grow following intracerebral inoculation of...

Topics

Animals
Evaluation Studies as Topic
Genetic Variation
Mice
Mice, Inbred BALB C
Nerve Tissue
Simplexvirus
Virulence
Virus Activation
Virus Replication

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Identifiers

PMID: 1321881
DOI: 10.1099/0022-1317-73-4-967

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1321881-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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