Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Peripheral replication and latency reactivation kinetics of the non-neurovirulent herpes simplex virus type 1 variant 1716.

The Journal of general virology - 1 Apr 1992

Robertson L M, MacLean A R, Brown S M

Abstract excerpt

The terminal portion of the herpes simplex virus (HSV) genome long repeat region has been shown to contain a neurovirulence gene. Both HSV-1 and HSV-2 mutants deleted in this gene fail to cause central nervous system (CNS) disease in mice. The HSV-1 strain 17 variant 1716, which has a 759 bp deletion encompassing the gene, grows normally in tissue culture but fails to grow following intracerebral inoculation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Evaluation Studies as Topic
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Inbred BALB C

Share to Simplexvirus

Share to Virulence

Share to Virus Activation

Share to Virus Replication

Source

Identifiers

PMID: 1321881
DOI: 10.1099/0022-1317-73-4-967

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Peripheral replication and latency reactivation kinetics of the non-neurovirulent herpes simplex virus type 1 variant 1716.PMID 1321881Read ↗

Replication of the herpes simplex virus type 1 RL1 mutant 1716 in primary neuronal cell cultures--possible relevance to use as a viral vector.Semantic proximity Read ↗

The herpes simplex virus type 1 strain 17+ gamma 34.5 deletion mutant 1716 is avirulent in SCID mice.Semantic proximity Read ↗

Herpes simplex virus type 1 deletion variants 1714 and 1716 pinpoint neurovirulence-related sequences in Glasgow strain 17+ between immediate early gene 1 and the 'a' sequence.Semantic proximity Read ↗

The Latent Herpes Simplex Virus Type 1 Genome Copy Number in Individual Neurons Is Virus Strain Specific and Correlates with ReactivationSemantic proximity Read ↗

Herpes simplex virus type 1 dUTPase mutants are attenuated for neurovirulence, neuroinvasiveness, and reactivation from latencySemantic proximity Read ↗

Latent phenotype analysis of three deletion variants of herpes simplex virus type 1 (HSV-1) in mouse model.Semantic proximity Read ↗

Evidence that the herpes simplex virus type 1 uracil DNA glycosylase is required for efficient viral replication and latency in the murine nervous systemSemantic proximity Read ↗

Herpes simplex virus 1 strain 17+ with R2 mutation in UL37 has residual retrograde transport.Semantic proximity Read ↗

Histopathological responses in the CNS following inoculation with a non-neurovirulent mutant (1716) of herpes simplex virus type 1 (HSV 1): relevance for gene and cancer therapy.Semantic proximity Read ↗

A replication competent HSV-1(McKrae) with a mutation in the amino-terminus of glycoprotein K (gK) is unable to infect mouse trigeminal ganglia after cornea infection.Semantic proximity Read ↗

A human sensory neuron model for varicella-zoster virus latency and reactivation <i>in vitro</i>Semantic proximity Read ↗

Modeling HSV-1 Latency in Human Embryonic Stem Cell-Derived NeuronsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.