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Molecular and biological characterization of a herpes simplex virus type 1 (HSV-1) neuroinvasiveness gene.

1 Aug 1990

Abstract excerpt

Pathogenetic studies of herpes simplex virus type 1 (HSV-1) strains ANG and its mouse brain-passaged descendant ANG path revealed no difference in neurovirulence but a significant difference in neuroinvasiveness. Thus, both viruses induced a fatal encephalitis in mice after direct injection into the brain, but only ANG path induced lethal neurologic disease after inoculation on rear footpads. The difference in...

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PMID: 2165127
DOI: 10.1084/jem.172.2.487

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