Article
Persistent infection of a glioma cell line generates a Theiler's virus variant which fails to induce demyelinating disease in SJL/J mice.
The Journal of general virology - 1 Sept 1990
Patick A K, Oleszak E L, Leibowitz J L, Rodriguez M
Abstract excerpt
Theiler's murine encephalomyelitis virus (TMEV) induces demyelinating disease which is associated with persistent virus infection of the central nervous system. To study the interaction between TMEV and host cells, we infected the G26-20 glioma cell line in vitro, and this resulted in a lytic inf...
Topics
- Animals
- Antibodies, Viral
- Antigens, Viral
- Cell Line
- Cell Transformation, Viral
- Demyelinating Diseases
- Female
- Genetic Variation
- Glioma
- Immunoglobulins
- Maus Elberfeld virus
- Mice
- Mice, Inbred Strains
- RNA, Viral
- Spinal Cord
- Viral Plaque Assay
- Virulence
- Virus Replication