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Article

A matrix-assisted laser desorption/ionization time-of-flight based method for screening the 1691G --> A mutation in the factor V gene.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Mar 2002

Hung K, Sun X, Ding H, Kalafatis M, Simioni P, Guo B

Abstract excerpt

A point mutation, 1691 G --> A in the coagulation factor V gene results in an Arg506 --> Gln amino acid substitution in the factor V molecule. This mutation, defined as factor VLEIDEN, results in activated protein C (APC) resistance and is the most common genetic risk factor for familial thrombophilia. A new mini-sequencing method using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass...

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Source

Identifiers

PMID: 11914653
DOI: 10.1097/00001721-200203000-00006

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A matrix-assisted laser desorption/ionization time-of-flight based method for screening the 1691G --> A mutation in the factor V gene.PMID 11914653Read ↗

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Validation of the minisequencing method for detection of G1691A (Leiden) factor V mutation.Semantic proximity Read ↗

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