CCR5 coreceptor usage of non-syncytium-inducing primary HIV-1 is independent of phylogenetically distinct global HIV-1 isolates: delineation of consensus motif in the V3 domain that predicts CCR-5 usage.

doi:10.1006/viro.1997.8924

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Article

CCR5 coreceptor usage of non-syncytium-inducing primary HIV-1 is independent of phylogenetically distinct global HIV-1 isolates: delineation of consensus motif in the V3 domain that predicts CCR-5 usage.

Virology - 5 Jan 1998

Xiao L, Owen S M, Goldman I, Lal A A, deJong J J, Goudsmit J, Lal R B

Abstract excerpt

The cellular tropism of human immunodeficiency virus type 1 (HIV-1) is dependent on utilization of specific chemokine co-receptor: macrophage-tropic/non-syncytium-inducing (NSI) viruses use CCR5, whereas T-cell tropic/syncytium-inducing (SI) viruses preferentially use CXCR4. We have analyzed co-r...

Topics

Amino Acid Sequence
CD4-Positive T-Lymphocytes
Cell Line
Cells, Cultured
Chemokines
Consensus Sequence
Gene Products, env
Genotype
Giant Cells
HIV-1
Homozygote
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutagenesis, Site-Directed

Phenotype

Phylogeny

Receptors, CCR5

Receptors, CXCR4

Source

Open in PubMed

Identifiers

PMID: 9448692
DOI: 10.1006/viro.1997.8924

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9448692-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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