Article
Deletion and differential expression of p16INK4a in mouse lung tumors.
Carcinogenesis - 1 Jan 1997
Belinsky S A, Swafford D S, Middleton S K, Kennedy C H, Tesfaigzi J
Abstract excerpt
Recent allelotyping of chemical-induced lung tumors in hybrid mice has detected loss of heterozygosity on chromosome 4 in a region involving the interferon-alpha (IFN-alpha gene cluster that is syntenic to human chromosome 9p21-22, the location of the p16INK4a (p16) and p15INK4b (p15) tumor suppressor genes. The purpose of the current investigation was to characterize the expression of p16 and p15 in lung tumors...
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