Article
Deletion and differential expression of p16INK4a in mouse lung tumors.
Carcinogenesis - 1 Jan 1997
Belinsky S A, Swafford D S, Middleton S K, Kennedy C H, Tesfaigzi J
Abstract excerpt
Recent allelotyping of chemical-induced lung tumors in hybrid mice has detected loss of heterozygosity on chromosome 4 in a region involving the interferon-alpha (IFN-alpha gene cluster that is syntenic to human chromosome 9p21-22, the location of the p16INK4a (p16) and p15INK4b (p15) tumor suppr...
Topics
- Animals
- Carrier Proteins
- Cell Cycle Proteins
- Chromosome Mapping
- Cyclin D1
- Cyclin-Dependent Kinase Inhibitor p15
- Cyclin-Dependent Kinase Inhibitor p16
- Cyclins
- Gene Deletion
- Gene Expression Regulation, Neoplastic
- Genes, Tumor Suppressor
- Lung Neoplasms
- Methylation
- Mice
- Mice, Inbred A
- Mutation
- Oncogene Proteins
- RNA, Messenger