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Article

Allelotype analysis in mouse hepatocellular carcinomas; frequent homozygous deletion of mouse homolog of p16/CDKN2 gene on chromosome 4 in culture.

Biological & pharmaceutical bulletin - 1 May 1996

Miyasaka K, Fukui T, Kitagawa T

Abstract excerpt

Because allelotype analysis of many tumors has been important in the identification of new tumor suppressor genes, here we have analyzed hepatocellular carcinomas (HCCs) derived from F1 hybrid mice between C3H and MSM in detail. The analysis showed no allelic loss in primary HCCs, while the loss...

Topics

Alleles
Animals
Carrier Proteins
Chromosomes
Cyclin-Dependent Kinase Inhibitor p16
DNA
Diethylnitrosamine
Female
Gene Deletion
Genes, Tumor Suppressor
Homozygote
Liver Neoplasms, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Polymorphism, Restriction Fragment Length

Source

Identifiers

PMID: 8741575
DOI: 10.1248/bpb.19.683

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8741575-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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