Article
B-cell proliferation initiated by Ia cross-linking and sustained by interleukins leads to class switching but not somatic mutation in vitro.
Immunology - 1 Jan 1992
Wysocki L J, Creadon G, Lehmann K R, Cambier J C
Abstract excerpt
Somatic mutations that are acquired by antibody V genes of antigen-stimulated B cells ultimately provide the clonal diversity from which memory B cells are selected during immune responses to T-cell-dependent antigens. Somatic mutations apparently are not acquired when B cells are stimulated by m...
Topics
- Animals
- B-Lymphocytes
- Base Sequence
- Cells, Cultured
- DNA
- Genes, Immunoglobulin
- Histocompatibility Antigens Class II
- Immunoglobulin Isotypes
- Interleukin-4
- Mice
- Mice, Inbred Strains
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Signal Transduction