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Article

Absence of association between a common mutation in the methylenetetrahydrofolate reductase gene and the risk of coronary artery disease.

European journal of clinical investigation - 1 Jan 1998

Reinhardt D, Sigusch H H, Vogt S F, Farker K, Müller S, Hoffmann A

Abstract excerpt

BACKGROUND: Elevated total plasma homocysteine levels are associated with an increased risk of coronary artery disease. Plasma homocysteine levels are influenced by nutritional and hereditary factors. A point mutation (cytosin to thymidine substitution; C677-->T) in the gene encoding methylenetet...

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Source

Identifiers

PMID: 9502183
DOI: 10.1046/j.1365-2362.1998.00242.x

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-9502183-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Absence of association between a common mutation in the methylenetetrahydrofolate reductase gene and the risk of coronary artery disease.PMID 9502183Read ↗

A common mutation in methylenetetrahydrofolate reductase gene is not a major risk of coronary artery disease or myocardial infarction.Semantic proximity Read ↗

A mutation in the methylenetetrahydrofolate reductase gene is not associated with increased risk for coronary artery disease or myocardial infarction.Semantic proximity Read ↗

Homocysteine and risk of premature coronary heart disease. Evidence for a common gene mutation.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase gene and coronary artery disease.Semantic proximity Read ↗

Mutation A1298C of methylenetetrahydrofolate reductase: risk for early coronary disease not associated with hyperhomocysteinemia.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase C677T mutation, plasma homocysteine, and folate in subjects from northern Italy with or without angiographically documented severe coronary atherosclerotic disease: evidence for an important genetic-environmental interaction.Semantic proximity Read ↗

C677T mutation of methylenetetrahydrofolate reductase gene and serum homocysteine levels in Turkish patients with coronary artery disease.Semantic proximity Read ↗

Identification of six methylenetetrahydrofolate reductase (MTHFR) genotypes resulting from common polymorphisms: impact on plasma homocysteine levels and development of coronary artery disease.Semantic proximity Read ↗

Association of polymorphism in the thermolabile 5, 10-methylene tetrahydrofolate reductase gene and hyperhomocysteinemia with coronary artery disease.Semantic proximity Read ↗

[MTHFR genetic variability on coronary artery disease development].Semantic proximity Read ↗

The 677C-->T mutation in the methylenetetrahydrofolate reductase gene: associations with plasma total homocysteine levels and risk of coronary atherosclerotic disease.Semantic proximity Read ↗

Distribution in healthy and coronary populations of the methylenetetrahydrofolate reductase (MTHFR) C677T mutation.Semantic proximity Read ↗

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