Genetic polymorphism of methylenetetrahydrofolate reductase and myocardial infarction. A case-control study.

doi:10.1161/01.cir.94.8.1812

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Article

Genetic polymorphism of methylenetetrahydrofolate reductase and myocardial infarction. A case-control study.

Circulation - 15 Oct 1996

Schmitz C, Lindpaintner K, Verhoef P, Gaziano J M, Buring J

Abstract excerpt

BACKGROUND: Elevated total plasma homocyst(e)ine (tHcy; the composite of homocysteine-derived moieties in their oxidized and reduced forms) levels are a risk factor for coronary heart disease, stroke, and venous thrombosis. tHcy plasma levels are influenced by folate, vitamins B6 and B12, as well...

Topics

Aged
Case-Control Studies
Female
Folic Acid
Genotype
Homocysteine
Humans
Male
Methylenetetrahydrofolate Reductase (NADPH2)
Middle Aged
Mutation
Myocardial Infarction
Oxidoreductases Acting on CH-NH Group Donors
Polymorphism, Genetic
Risk Factors

Source

Open in PubMed

Identifiers

PMID: 8873653
DOI: 10.1161/01.cir.94.8.1812

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8873653-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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