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Article

Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection.

Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 1997

Price D A, Goulder P J, Klenerman P, Sewell A K, Easterbrook P J, Troop M, Bangham C R, Phillips R E

Abstract excerpt

Cytotoxic T lymphocytes (CTLs) are thought to play a crucial role in the termination of the acute primary HIV-1 syndrome, but clear evidence for this presumption has been lacking. Here we demonstrate positive selection of HIV-1 proviral sequences encoding variants within a CTL epitope in Nef, a gene product critical for viral pathogenicity, during and after seroconversion. These positively selected HIV-1 variants...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 9050875
DOI: 10.1073/pnas.94.5.1890
PMCID: PMC20013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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