Article
Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression.
Nature medicine - 1 Apr 1995
Koenig S, Conley A J, Brewah Y A, Jones G M, Leath S, Boots L J, Davey V, Pantaleo G, Demarest J F, Carter C
Abstract excerpt
An HIV-1-seropositive volunteer was infused with an expanded autologous cytotoxic T lymphocyte (CTL) clone directed against the HIV-1 nef protein. This clone was adoptively transferred to determine whether supplementing CTL activity could reduce viral load or improve clinical course. Unexpectedly...
Topics
- Acquired Immunodeficiency Syndrome
- Amino Acid Sequence
- Base Sequence
- CD4 Lymphocyte Count
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- DNA Primers
- DNA, Viral
- Disease Progression
- Gene Amplification
- Gene Products, nef
- HIV Antibodies
- HIV Core Protein p24