Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A CCHC metal-binding domain in Nanos is essential for translational regulation.

The EMBO journal - 17 Feb 1997

Curtis D, Treiber D K, Tao F, Zamore P D, Williamson J R, Lehmann R

Abstract excerpt

The Drosophila Nanos protein is a localized repressor of hunchback mRNA translation in the early embryo, and is required for the establishment of the anterior-posterior body axis. Analysis of nanos mutants reveals that a small, evolutionarily conserved, C-terminal region is essential for Nanos function in vivo, while no other single portion of the Nanos protein is absolutely required. Within the C-terminal region...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Drosophila melanogaster
Share to Drosophila Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Molecular Sequence Data

Share to Mutation

Share to Protein Binding

Share to Recombinant Fusion Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 9049312
DOI: 10.1093/emboj/16.4.834
PMCID: PMC1169684

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A CCHC metal-binding domain in Nanos is essential for translational regulation.PMID 9049312Read ↗

A selective screen reveals discrete functional domains in Drosophila Nanos.Semantic proximity Read ↗

The Pumilio protein binds RNA through a conserved domain that defines a new class of RNA-binding proteins.Semantic proximity Read ↗

Drosophila Brain Tumor is a translational repressor.Semantic proximity Read ↗

Recognition and long-range interactions of a minimal nanos RNA localization signal element.Semantic proximity Read ↗

Distinct cis elements in the 3' UTR of the C. elegans cebp-1 mRNA mediate its regulation in neuronal development.Semantic proximity Read ↗

Overlapping but distinct RNA elements control repression and activation of nanos translation.Semantic proximity Read ↗

Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28.Semantic proximity Read ↗

Binding of pumilio to maternal hunchback mRNA is required for posterior patterning in Drosophila embryos.Semantic proximity Read ↗

Drosophila Cup is an eIF4E-binding protein that functions in Smaug-mediated translational repression.Semantic proximity Read ↗

Unraveling the RNA Binding Properties of the Iron-Sulfur Zinc Finger Protein CPSF30.Semantic proximity Read ↗

A common translational control mechanism functions in axial patterning and neuroendocrine signaling in Drosophila.Semantic proximity Read ↗

CCHX zinc finger derivatives retain the ability to bind Zn(II) and mediate protein-DNA interactions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.