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Article

Unraveling the RNA Binding Properties of the Iron-Sulfur Zinc Finger Protein CPSF30.

Biochemistry - 3 Mar 2020

Pritts Jordan D, Hursey Matthew S, Michalek Jamie L, Batelu Sharon, Stemmler Timothy L, Michel Sarah L J

Abstract excerpt

Cleavage and polyadenylation specificity factor 30 (CPSF30) is a "zinc finger" protein that plays a crucial role in the transition of pre-mRNA to RNA. CPSF30 contains five conserved CCCH domains and a CCHC "zinc knuckle" domain. CPSF30 activity is critical for pre-mRNA processing. A truncated form of the protein, in which only the CCCH domains are present, has been shown to specifically bind AU-rich pre-mRNA...

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Identifiers

PMID: 32027124
DOI: 10.1021/acs.biochem.9b01065
PMCID: PMC8575264

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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