Article
A common translational control mechanism functions in axial patterning and neuroendocrine signaling in Drosophila.
Development (Cambridge, England) - 1 Jul 2002
Clark Ira E, Dobi Krista C, Duchow Heather K, Vlasak Anna N, Gavis Elizabeth R
Abstract excerpt
Translational repression of maternal nanos (nos) mRNA by a cis-acting Translational Control Element (TCE) in the nos 3'UTR is critical for anterior-posterior patterning of the Drosophila embryo. We show, through ectopic expression experiments, that the nos TCE is capable of repressing gene expression at later stages of development in neuronal cells that regulate the molting cycle. Our results predict additional...
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