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Article

Binding of pumilio to maternal hunchback mRNA is required for posterior patterning in Drosophila embryos.

Cell - 10 Mar 1995

Murata Y, Wharton R P

Abstract excerpt

Posterior patterning in Drosophila embryos is governed by nanos (nos), which acts by repressing the translation of maternal transcripts of the hunchback (hb) gene. Sites in hb mRNA that mediate this repression, named nanos response elements (NREs), have been identified. However, we know of no evidence of a direct interaction between nos, or any other protein, and the NRE. Here, we show that two proteins present...

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Identifiers

PMID: 7889568
DOI: 10.1016/0092-8674(95)90353-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Binding of pumilio to maternal hunchback mRNA is required for posterior patterning in Drosophila embryos.PMID 7889568Read ↗

The Pumilio protein binds RNA through a conserved domain that defines a new class of RNA-binding proteins.Semantic proximity Read ↗

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Maternal Pumilio acts together with Nanos in germline development in Drosophila embryos.Semantic proximity Read ↗

Drosophila Brain Tumor is a translational repressor.Semantic proximity Read ↗

A common translational control mechanism functions in axial patterning and neuroendocrine signaling in Drosophila.Semantic proximity Read ↗

Translational regulation of oskar mRNA by bruno, an ovarian RNA-binding protein, is essential.Semantic proximity Read ↗

Nanos and Pumilio have critical roles in the development and function of Drosophila germline stem cells.Semantic proximity Read ↗

The NHL domain of BRAT is an RNA-binding domain that directly contacts the hunchback mRNA for regulation.Semantic proximity Read ↗

Recognition and long-range interactions of a minimal nanos RNA localization signal element.Semantic proximity Read ↗

A morphogenetic gradient of hunchback protein organizes the expression of the gap genes Krüppel and knirps in the early Drosophila embryo.Semantic proximity Read ↗

Target sequences for hunchback in a control region conferring Ultrabithorax expression boundaries.Semantic proximity Read ↗

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