Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Pumilio protein binds RNA through a conserved domain that defines a new class of RNA-binding proteins.

RNA (New York, N.Y.) - 1 Dec 1997

Zamore P D, Williamson J R, Lehmann R

Abstract excerpt

Translation of hunchback(mat) (hb[mat]) mRNA must be repressed in the posterior of the pre-blastoderm Drosophila embryo to permit formation of abdominal segments. This translational repression requires two copies of the Nanos Response Element (NRE), a 16-nt sequence in the hb[mat] 3' untranslated region. Translational repression also requires the action of two proteins: Pumilio (PUM), a sequence-specific...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to DNA-Binding Proteins
Share to Molecular Sequence Data

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to RNA, Messenger

Share to Sequence Homology, Amino Acid

Share to Species Specificity

Share to Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 9404893
PMCID: PMC1369583

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Pumilio protein binds RNA through a conserved domain that defines a new class of RNA-binding proteins.PMID 9404893Read ↗

No significant regulation of bicoid mRNA by Pumilio or Nanos in the early Drosophila embryo.Semantic proximity Read ↗

Binding of pumilio to maternal hunchback mRNA is required for posterior patterning in Drosophila embryos.Semantic proximity Read ↗

The NHL domain of BRAT is an RNA-binding domain that directly contacts the hunchback mRNA for regulation.Semantic proximity Read ↗

Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptomeSemantic proximity Read ↗

Drosophila Brain Tumor is a translational repressor.Semantic proximity Read ↗

Brain tumor is a sequence-specific RNA-binding protein that directs maternal mRNA clearance during the Drosophila maternal-to-zygotic transition.Semantic proximity Read ↗

Human Pumilio proteins use fuzzy multivalent hydrophobic interactions to recruit the CCR4–NOT deadenylase complex to repress mRNAsSemantic proximity Read ↗

A conserved abundant cytoplasmic long noncoding RNA modulates repression by Pumilio proteins in human cellsSemantic proximity Read ↗

The RNA binding domain of Pumilio antagonizes poly-adenosine binding protein and accelerates deadenylation.Semantic proximity Read ↗

Bespoke RNA recognition by Pumilios.Semantic proximity Read ↗

Sequential regulation of maternal mRNAs through a conserved cis-acting element in their 3’UTRsSemantic proximity Read ↗

Patterns and plasticity in RNA-protein interactions enable recruitment of multiple proteins through a single site.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.